Showing posts with label How our Genes can predict if medication can help quit smoking. Show all posts
Showing posts with label How our Genes can predict if medication can help quit smoking. Show all posts

Thursday, May 31, 2012

How our Genes can predict if medication can help quit smoking


Why some people cannot stop smoking?


The fact that trying to quit smoking is an expensive proposition makes it difficult for many. Whilst the cost of cigarettes continues to inflate out of proportion, it's still cheaper to smoke than to try to quit. What smokers need to remember is that once the habit is gone from their lives, they will save a huge amount of money on cigarettes and return to a normal life without the burden of smoking? The social factor is another reason why people can't quit smoking. Unless a person surrounds him or herself with other non-smokers, it can be a challenge to not light up when others are. Attending parties, meeting for coffee and any number of other instances are made more challenging when one's friends or associates smoke. One will offer a cigarette and it can be hard to refuse.




Most smokers are aware of the risks for lung disease and cardiovascular disease, but smoking affects nearly every organ in your body. Research has shown that smoking causes more than 25 different diseases.

Short term effects of smoking


If you decide to stop smoking, you will experience immediate improvement of your health. The body starts healing itself within 20 minutes after quitting and all of the below short term health effects of smoking will improve.





•Blood pressure increases

•Pulse rate increases

•Body temperature of hands and feet drops

•Chances of having a heart attack increases

•Decreased ability to taste and smell

•Decreased lung function

•Decreased circulation

•Coughs

•Colds

•Bronchitis

•Shortness of breath

•Smoking during pregnancy increases the chance for premature birth and respiratory illnesses.




Long term effects of smoking


The long term effects of smoking are severe. A number of diseases can be caused by smoking, they include:

•Cardiovascular disease

•Lung cancer

•Chronic obstructive pulmonary diseases (chronic bronchitis, emphysema)

•Cancer of the mouth, throat, stomach, bladder, kidneys , pancreas, and cervix and other cancers.

Smoking cessation will reduce the chances of obtaining long term effects of smoking and if disease caused by smoking is already present, there are still great short and long term health benefits.

New Research will help us to know who can quit smoking….


The same gene variations that make it difficult to stop smoking also increase the likelihood that heavy smokers will respond to nicotine-replacement therapy and drugs that thwart cravings, a new study shows. The research, led by investigators at Washington University School of Medicine in St. Louis, will appear online May 30 in the American Journal of Psychiatry. The study suggests it may one day be possible to predict which patients are most likely to benefit from drug treatments for nicotine addiction.


Smokers whose genetic makeup puts them at the greatest risk for heavy smoking, nicotine addiction and problems kicking the habit also appear to be the same people who respond most robustly to pharmacologic therapy for smoking cessation,” says senior investigator Laura Jean Bierut, MD, professor of psychiatry. “Our research suggests that a person’s genetic makeup can help us better predict who is most likely to respond to drug therapy so we can make sure those individuals are treated with medication in addition to counseling or other interventions. For the new study, the researchers analyzed data from more than 5,000 smokers who participated in community-based studies and more than 1,000 smokers in a clinical treatment study. The scientists focused on the relationship between their ability to quit smoking successfully and genetic variations that have been associated with risk for heavy smoking and nicotine dependence. People with the high-risk genetic markers smoked an average of two years longer than those without these high-risk genes, and they were less likely to quit smoking without medication,” says first author Li-Shiun Chen, MD, assistant professor of psychiatry at Washington University. “The same gene variants can predict a person’s response to smoking-cessation medication, and those with the high-risk genes are more likely to respond to the medication.



In the clinical treatment trial, individuals with the high-risk variants were three times more likely to respond to drug therapy, such as nicotine gum, nicotine patches, the antidepressant buproprion and other drugs used to help people quit. Tobacco use is the leading cause of preventable illness and death in the United States and a major public health problem worldwide. Cigarette smoking








contributes to the deaths of an estimated 443,000 Americans each year. Although lung cancer is the leading cause of smoking-related cancer death among both men and women, tobacco also contributes to other lung problems, many other cancers and heart attacks. Bierut and Chen say that the gene variations they studied are not the only ones involved in whether a person smokes becomes addicted to nicotine or has difficulty quitting. But they contend that because the same genes can predict both heavy smoking and enhanced response to drug treatment, the genetic variants are important to the addiction puzzle. “It’s almost like we have a ‘corner piece’ here,” Beirut says. “It’s a key piece of the puzzle, and now we can build on it. Clearly these genes aren’t the entire story — other genes play a role, and environmental factors also are important. But we’ve identified a group that’s responding to pharmacologic treatment and a group that’s not responding, and that’s a key step in improving, and eventually tailoring, treatments to help people quit smoking. Since people without the risky genetic variants aren’t as likely to respond to drugs, Beirut says they should get counseling or other non-drug therapies.



This is an actionable genetic finding, Chen says. Scientific journals publish genetic findings every day, but this one is actionable because treatment could be based on a person’s genetic makeup. I think this study is moving us closer to personalized medicine, which is where we want to go. And Beirut says that although earlier studies suggested the genes had only a modest influence on smoking and addiction, the new clinical findings indicate the genetic variations are having a big effect on treatment response. These variants make a very modest contribution to the development of nicotine addiction, but they have a much greater effect on the response to treatment. That’s a huge finding,” she says.

(Source- American Journal of Psychiatry)

Lastly some common ideas for quit smoking

1. Nicotine replacement products:



  • Nicotine patch
  • Nicotine gum
  • Nicotine inhaler
  • Nicotine lozenges
  • Nicotine nasal spray
2. Hypnosis
 
Hypnosis puts people into an altered state of consciousness where they are more open to suggestion.
 
3. Zyban
 
Zyban (Bupropion hydrochloride) is originally an anti-depressant. Users of this drug reported a loss of interest in smoking, which is how zyban was discovered as a stop smoking pill.
 
4. Chantix
 
Chantix is a stop smoking pill that blocks nicotine receptors in the brain, which reduces the cravings when you quit smoking
 
Other quit smoking aids
 
5.Laser therapy
 
6• Acupuncture
 
7• Herbs


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